Coronavirus. Pandemic. Zoonotic disease. Viral transmission. Over the past one-and-a-half years, the world has been forced to familiarise itself with the aforementioned terms, owing to its battle against the COVID-19 pandemic. If we aren’t careful, these words could continue being a part of our everyday lives in newer ways, a new study has warned.
An international team of researchers has found that the Middle East respiratory syndrome coronavirus (MERS‐CoV), which causes the Middle East respiratory syndrome, is just a few mutations away from becoming a serious pandemic threat!
But before we understand how it could potentially trigger another pandemic, let us first understand what the disease itself is.
What is Middle East respiratory syndrome?
As per the World Health Organisation (WHO), the Middle East respiratory syndrome (MERS) is a viral respiratory disease that was first identified in Saudi Arabia back in 2012. It is highly lethal, with approximately 35% of reported patients with MERS-CoV infection having succumbed to the disease.
Just like COVID-19, the clinical spectrum of MERS-CoV infection ranges from no symptoms (asymptomatic) or mild respiratory symptoms to severe acute respiratory disease and death. Typical MERS symptoms include fever, cough and shortness of breath.
Most human cases of MERS-CoV infections have been attributed to human-to-human infections in healthcare settings. However, the virus does not seem to pass easily from person to person unless there is close contact—like the kind that occurs when providing unprotected care to a patient. Such healthcare-associated MERS outbreaks have occurred in several countries in the past, with the largest seen in Saudi Arabia, the United Arab Emirates, and the Republic of Korea.
The disease is caused by the coronavirus named MERS-CoV—a zoonotic virus that was transmitted to humans through direct or indirect contact with infected dromedary camels (Arabian camels). MERS-CoV has been identified in dromedaries in several countries in the Middle East, Africa and South Asia.
What does the new research say?
Since the initial MERS outbreak, researchers have found that up to 80% of dromedaries that have been tested—70% of which live in Africa—have antibodies for MERS-CoV. This very finding raises the question as to why more African people have not been infected by the virus, considering the high number of dromedaries and their interactions with humans on the African continent.
To answer this mystery, the researchers conducted a new study wherein they collected samples of the virus from a variety of places in the Middle East and Africa and grouped them into different clades (natural groups). After comparing the samples genetically and under lab conditions using human lung cells, they found that the variants originating in Arabian clades were easily transmissible to humans, while the variants in African clades were not.
Closer examination revealed that the differences between the variants came down to amino acids in the S protein. In fact, the African variant had to be genetically engineered to have the same amino acids as the Middle Eastern variant, for it to possess the ability to easily infect human cells.
These results led the researchers to believe that the reason why the African variant has not mutated to infect humans is due to the one-way nature of the dromedary trade—the animals are only being traded from Africa to the Middle East.
But if the trade reverses at some point, or another animal becomes a carrier and is traded to Africa, mutations could arise. And once this ball of mutations gets rolling, researchers conclude that it could potentially set off a health crisis in Africa, and even give rise to another deadly pandemic!
The study and its results have been published in the journal Proceedings of the National Academy of Sciences and can be accessed here.
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Updated 4:49 PM ET, Thu December 24, 2020Kinshasa, Democratic Republic of the Congo — Showing early symptoms of hemorrhagic fever, the patient sits quietly on her bed, wrangling two toddlers desperate to flee the cell-like hospital room in Ingende, a remote town in the Democratic Republic of the Congo (DRC).They are waiting for the results of a test for Ebola.The patient can only communicate with her relatives through a clear plastic observation window. Her identity is secret, to protect her from being ostracized by locals fearful of Ebola infection. Her children have also been tested but, for now, show no symptoms.There is a vaccine and a treatment for Ebola, which have brought down the rate at which it kills.But the question at the back of everyone’s mind is: What if this woman doesn’t have Ebola? What if, instead, she is patient zero of “Disease X,” the first known infection of a new pathogen that could sweep the world as fast as Covid-19, but one that has Ebola’s 50% to 90% fatality rate?”Disease X” is hypothetical for now, an outbreak that scientists and public health experts fear could lead to serious disease around the world if and when it occurs, according to WHO. “X” stands for unexpected.Doctor Dadin Bonkole works at the Ingende Hospital’s Ebola Red Zone.This isn’t the stuff of science fiction. It’s a scientific fear, based on scientific facts.”We’ve all got to be frightened,” the patient’s physician, Dr. Dadin Bonkole, said. “Ebola was unknown. Covid was unknown. We have to be afraid of new diseases.”
Threat to humanity
Humanity faces an unknown number of new and potentially fatal viruses emerging from Africa’s tropical rainforests, according to Professor Jean-Jacques Muyembe Tamfum, who helped discover the Ebola virus in 1976 and has been on the frontline of the hunt for new pathogens ever since.”We are now in a world where new pathogens will come out,” he told CNN. “And that’s what constitutes a threat for humanity.”As a young researcher, Muyembe took the first blood samples from the victims of a mysterious disease that caused hemorrhages and killed about 88% of patients and 80% of the staff who were working at the Yambuku Mission Hospital when the disease was first discovered. The vials of blood were sent to Belgium and the US, where scientists found a worm-shaped virus. They called it “Ebola,” after the river close to the outbreak in the country that was then known as Zaire. The identification of Ebola relied on a chain that connected the most remote parts of Africa’s rainforests to high-tech laboratories in the West.
New viruses on the rise
Since the first animal-to-human infection, yellow fever, was identified in 1901, scientists have found at least another 200 viruses known to cause disease in humans. According to research by Mark Woolhouse, professor of infectious disease epidemiology at the University of Edinburgh, new species of viruses are being discovered at a rate of three to four a year. The majority of them originate from animals.Experts say the rising number of emerging viruses is largely the result of ecological destruction and wildlife trade.As their natural habitats disappear, animals like rats, bats, and insects survive where larger animals get wiped out. They’re able to live alongside human beings and are frequently suspected of being the vectors that can carry new diseases to humans.A passenger boat stops for a break on the shores of Ingende. These boats can take weeks to make their way down-river to Kinshasa.Scientists have linked past Ebola outbreaks to heavy human incursion into the rainforest. In one 2017 study, researchers used satellite data to determine that 25 of the 27 Ebola outbreaks located along the limits of the rainforest biome in Central and West Africa between 2001 and 2014 began in places that had experienced deforestation about two years prior. They added that zoonotic Ebola outbreaks appeared in areas where human population density was high and where the virus has favorable conditions, but that the relative importance of forest loss is partially independent of these factors.In the first 14 years of the 21st century, an area larger than the size of Bangladesh was felled in the Congo River basin rainforest.The United Nations has warned that if the current deforestation and population growth trends continue, the country’s rainforest may have completely disappeared by the end of the century. As that happens, animals and the viruses they carry will collide with people in new and often disastrous ways.It doesn’t have to be this way.A multidisciplinary group of scientists based across the US, China, Kenya and Brazil has calculated that a global investment of $30 billion a year into projects to protect rainforests, halt the wildlife trade and farming would be enough to offset the cost of preventing future pandemics.Related: Democratic Republic of the Congo declares the end to its 11th Ebola outbreakWriting in the journal Science, the group said spending $9.6 billion a year on global forest protection schemes could lead to a 40% reduction in global deforestation in areas at the highest risk of virus spillover. This could include incentivizing the people living in and making their living from the forests, and banning widespread logging and the commercialization of the wildlife trade.A similar program in Brazil led to a 70% decline in deforestation between 2005 and 2012, the scientists said.While $30 billion a year may sound like a lot, scientists argue that the investment would quickly pay for itself. The coronavirus pandemic will cost the US alone an estimated $16 trillion over the next 10 years, according to Harvard economists David Cutler and Larry Summers, the former US Treasury Secretary. The IMF estimates that globally, the pandemic will cost $28 trillion in lost output between 2020 and 2025, relative to pre-pandemic projections.
The early warning system
Muyembe now runs the INRB in Kinshasa.While some scientists still sit in the cramped offices in the old INRB compound where Muyembe first worked on Ebola, brand-new laboratories opened in February. The INRB is supported by Japan, the US, the World Health Organization, the EU and other international donors including NGOs, foundations and academic institutionsWith Biosafety Level 3 labs, genome sequencing capability and world-class equipment, these facilities are not an act of charitable aid — they’re a strategic investmentBacked by the US Centers for Disease Control and Prevention and the World Health Organization, these INRB labs are the world’s early warning system for new outbreaks of known diseases like Ebola, and — perhaps more importantly — for those illnesses we have yet to discover.”If a pathogen emerged from Africa it will take time to spread all over the world,” Muyembe said. “So, if this virus is detected early — like in my institution here — there will be opportunity for Europe [and the rest of the world] to develop new strategies to fight these new pathogens.”Muyembe has reconnaissance units on the frontline of the war against new pathogens. Doctors, virologists and researchers are working deep in the DRC’s interior, seeking out known and unknown viruses before they can cause new pandemics.Simon Pierre Ndimbo and Guy Midingi are ecologists and virus hunters in the DRC’s northwestern Équateur Province, where Ingende is located. They’re the tip of the spear in tracking and tracing signs of emerging infectious diseases (EIDs).On a recent expedition the pair collected 84 bats, painstakingly picking them from their nets and tying the squealing, nipping animals up into bags.”You have to be careful — if not, they bite,” explained Midingi, his hands double-gloved for protection.A single bat bite could be the moment a new disease makes the leap from animals to humans.Ndimbo says their priority is to look for signs of Ebola infection in the bats. The latest outbreak of the disease in the Équateur province has been traced to human-to-human transmission but also to a new strain that is asumed so have come from the forest reservoir. And no one knows where, or what, that reservoir is.Back at the lab in Mbandaka the bats are swabbed, and blood samples are taken to be tested for Ebola before being sent to the INRB for further tests. The bats are then released.Dozens of new coronaviruses have been found in bats over recent years. No one knows just how dangerous they may be to humans.At a lab in Mbandaka, ecologists prepare to take a blood sample from a bat captured in the forest.Exactly how Ebola first infected humans remains a mystery, but scientists believe zoonotic illnesses like Ebola and Covid-19 make the leap when wild animals are butchered.So-called “bushmeat” is the traditional source of protein for people living in the rainforests, but it is now traded far from where it’s sourced and exported globally. The UN estimates that as much as 5 million tons of bushmeat are taken from the Congo River basin each year.In Kinshasa, a market trader brandishes the smoked carcass of a colobus monkey, its teeth exposed in a gruesome, petrified grin — he’s selling the small primates for $22, though the price, he says, is “negotiable.”Colobus monkeys have been hunted to extinction in some parts of the DRC, but the trader says he could export scores of them to Europe by plane.”I have to be honest, it’s forbidden to send the monkeys,” he explains. “We have to cut their heads and arms off and pack them among the other meats.”He says he gets deliveries every week, often from Ingende, around 400 miles upriver — the same village where doctors live in fear of a new pandemic emerging.Adams Cassinga, CEO of Conserv Congo and a wildlife crime investigator, said investigations have shown that “in Kinshasa alone, we have between five and 15 tons of bushmeat exported … some goes to the Americas … but the biggest part goes to Europe. Mainly to Brussels, Paris and London.”Smoked monkeys, soot-blackened sections of python, and fly-blown hams of sitatunga, a water-dwelling antelope, are gruesome. But they’re unlikely to be carrying dangerous viruses, which would be killed by the cooking process — although scientists have warned that even cooked primate meat is not completely safe.The live animals in the so-called “wet” market pose a bigger threat.Here young crocodiles — snouts wired shut and legs tied up — writhe on top of one another. Traders offer barrels of giant land snails, tortoises and freshwater turtles. Elsewhere there are black markets from live chimpanzees, and more exotic animals, some traded into private collections, others heading for the pot.”Disease X” may be ticking away inside any one of these animals, brought to the metropolis by poor people serving the tastes of the rich for exotic meals and pets.Bushmeat market in Kinshasa Port. Smoked fish is for sale here.”Bushmeat here, in urban areas, unlike the popular misconception, it is not for the poor, it is for the rich and privileged, so you’ve got high-ranking officials who believe in superstition that if you consume a certain type of bushmeat, it will give you strength,” Cassinga said. “You also have people who consume it as a symbol of status. But also in the last 10 to 20 years we have experienced an influx of expatriates, mainly from Southeast Asia, and who demand to eat certain types of meat such as turtles, snakes, primates.”Scientists have previously linked these kinds of wet markets to zoonotic diseases. The H5N1 influenza virus, known as the avian flu, and SARS both emerged from them. The exact origin of the coronavirus that causes Covid-19 has not been confirmed. But the greatest suspicion for its source has fallen on “wet” markets where live animals are sold and butchered for meat.The commercialization of the bushmeat trade is a potential route for infection. It’s also a symptom of the devastation of the Congo tropical rainforest, the world’s second largest after the Amazon.Most of the destruction is driven by local farmers, who rely on the forest economically — 84% of forest clearance is to make room for small scale agriculture.Yet the slash and burn techniques used by the locals increase human exposure to this once-virgin territory and its wild animals, a major risk factor for disease.”If you go in the forest … you will change the ecology; and insects and rats will leave this place and come to the villages … so this is the transmission of the virus, of the new pathogens,” Muyembe said.Back in Ingende Hospital, the doctors are wearing as much protective gear as can be found: Goggles, yellow biohazard overalls, double gloves taped shut, hoods over their heads and shoulders, galoshes over their shoes, and complex facemasks.They are still worried that the female patient may be showing symptoms of an Ebola-like illness that is not, in fact, Ebola. It may be a new virus, it may also be one of the many diseases that afflict people here that are already known to science — but none of the tests done here have explained her high fever and diarrhea.”We get cases which look very much like Ebola, but then when we do the tests, they are negative,” said the head of medical services in Ingende, Dr. Christian Bompalanga.”We have to carry out additional examinations in order to see what is really going on … at the moment there are a couple of suspected cases over there,” he added, pointing to the isolation ward where the young woman and her kids are being treated. And weeks later there remains no clear diagnosis for her illness.Once a new virus begins circulating among humans, the consequences of a brief encounter at the edge of a forest or at a wet market could be devastating. Covid-19 has shown that. Ebola has proved it. And in most of the scientific publications there is an assumption that there will be more contagions coming as humans continue to destroy wilderness habitats. It’s not an “IF” it’s a “WHEN”.The solution is clear. Protect the forests to protect humanity — because Mother Nature has deadly weapons in her armory.This story has been updated to include what the “X” in “Disease X” stands for.
Video editing by CNN’s Mark Baron. Thanks to Dr. Meris Matondo and Dr. Richard Ekila from INRB, the Congo’s National Institute of Biomedical Research, for their guidance during the reporting of this story.
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